ASD is a neurodevelopmental condition marked by difficulties with social communication and interaction, as well as limited, repetitive patterns of actions, interests, or activities. Due to the lack of specific pharmacological treatment for ASD and the disorder's clinical heterogeneity, current biomarker research efforts are mostly focused on discovering markers for predicting ASD risk or assisting with diagnosis. ASD is a heterogeneous neurodevelopmental condition characterised by social communication and social interaction deficiencies, as well as limited, repeated patterns of actions, interests, or activities. In the United States, at least one out of every 59 children has ASD, though this figure is possibly underestimated. Neurotransmitters, cytokines, and indicators of mitochondrial dysfunction, oxidative stress, and impaired methylation have all been tested as blood-based biomarker candidates. Given the prevalence of ASD, incorporating demographic and clinical data into the study using machine learning may provide a more powerful examination of disease status and symptom severity.Clinical investigators have begun to look into the role of the OXT and AVP signalling pathways in idiopathic ASD based on these promising preclinical findings. Several studies have shown that blood OXT and AVP concentrations also predict social cognitive abilities in children with ASD, with the lowest neuropeptide levels showing the most social impairment. Several single nucleotide polymorphisms and haplotypes in the OXTR and AVPR1A genes have also been related to ASD risk and limited, repetitive behaviours, according to human genetic association studies. These results, although preliminary, indicate that differences in OXT and AVP biology could be linked to ASD susceptibility, but much remains unknown. This was the first research to incorporate unidimensional neuropeptide interventions into a multidimensional biomarker analysis to more effectively probe disease status and symptom severity in people with ASD. Low neuropeptide receptor gene expression predicted greater social impairments and stereotyped behaviours in children with ASD, and total neuropeptide receptor gene expression was identified as the main driver of group classification